(R)-N-Boc-2-hydroxymethylmorpholine → (R)-4-Methyl-2-(hydroxymethyl)morpholine

HRID 2262475노트

반응식

HRID 2262475 반응식
C(O[C:6]([N:8]1[CH2:13][CH2:12][O:11][C@@H:10]([CH2:14][OH:15])[CH2:9]1)=O)(C)(C)C.C(OC(N1CCO[C@H](CO)C1)=O)(C)(C)C>>[CH3:6][N:8]1[CH2:13][CH2:12][O:11][C@@H:10]([CH2:14][OH:15])[CH2:9]1

참가 물질

3

반응물 2

HCID 1512576(R)-N-Boc-2-hydroxymethylmorpholine2회HCID 1512577tert-Butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate

생성물 1

HCID 40152301(R)-4-Methyl-2-(hydroxymethyl)morpholine

실험 절차

(R)-(4-Methylmorpholin-2-yl)-methanol was prepared similar to the procedure described for Intermediate 10, but using (R)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 9) instead of (S)-2-hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester (Intermediate 8). The title compound was obtained as a colourless oil (560 mg, 77%).

후처리

  1. custom(R)-(4-Methylmorpholin-2-yl)-methanol was prepared similar to the procedure

출처 및 근거

ORD 기록
ord-9559d207592e41a0be638dc1a9a5e56d
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851471B2

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