3-(4-Fluorophenyl)-5-(trifluoromethyl)-1,2-oxazole → 1-[3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[O:10][N:9]=2)=[CH:4][CH:3]=1.C1(C2[C:27](C3N=CN(C4C=CC=CC=4)C=3)=[C:26](C(F)(F)F)[O:25]N=2)C=CC=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([C:26](=[O:25])[CH3:27])=[C:11]([C:13]([F:14])([F:16])[F:15])[O:10][N:9]=2)=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 7992143-(4-Fluorophenyl)-5-(trifluoromethyl)-1,2-oxazole

HCID 251304493-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole

생성물 1

HCID 673627021-[3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-ethanone수율 85%

실험 절차

As described for Example 1e, 3-(4-fluoro-phenyl)-5-trifluoromethyl-isoxazole (50.0 mg, 216 mmol), instead of 3-phenyl-4-(1-phenyl-1H-imidazol-4-yl)-5-trifluoromethyl-isoxazole, was converted to the title compound (50.2 mg, 85%) which was obtained as a light yellow oil. MS: m/e=272.1 [M−H]−.

출처 및 근거

ORD 기록: ord-36fcfed1ec024723b6f4c3abdf956651
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07851469B2

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