4-Fluoro-3-nitrobenzoic acid → 3-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid

HRID 2262732노트

반응식

HRID 2262732 반응식
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[C:8]([NH2:12])[CH:9]=[CH:10][CH:11]=1.F[C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C:15]=1[N+:23]([O-:25])=[O:24]>CN1C(=O)CCC1.O>[N+:23]([C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:14]=1[NH:12][C:8]1[CH:9]=[CH:10][CH:11]=[C:6]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[CH:7]=1)[C:18]([OH:20])=[O:19])([O-:25])=[O:24]

참가 물질

5

반응물 2

HCID 679874-Fluoro-3-nitrobenzoic acidHCID 110193903-(1,3-Thiazol-2-yl)aniline

생성물 1

HCID 575722503-Nitro-4-(3-thiazol-2-yl-phenylamino)benzoic acid수율 83.4%

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a solution of 3-thiazol-2-yl-phenylamine (14.0 g, 79 mmol) in anhydrous NMP (50 ml) was added 4-fluoro-3-nitrobenzoic acid (15.0 g, 127 mmol). The resultant mixture was stirred at 90° C. over night. The cooled reaction cake was suspended in water and the solid was filtered off, washed with water and dried in the air to afford the desired product (22.5 g, 83%).

후처리

  1. customThe cooled reaction cake
  2. filtrationthe solid was filtered off
  3. washwashed with water
  4. customdried in the air

출처 및 근거

ORD 기록
ord-6e4db7c9b4af47d48f91526c47b2ec4b
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851490B2

반응 노트

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