Methanol → 4-Methoxy-3-methyl-4-oxobutanoic acid

반응식

C[O:2][C:3](=[O:10])[CH2:4][C:5](=[CH2:9])[C:6]([OH:8])=[O:7].[H][H].[CH3:13]O>>[CH3:13][O:8][C:6](=[O:7])[CH:5]([CH3:9])[CH2:4][C:3]([OH:2])=[O:10]

참가 물질

반응물 3

HCID 887Methanol2회

HCID 817914-Methyl hydrogen 2-methylenesuccinate

HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 139255704-Methoxy-3-methyl-4-oxobutanoic acid

실험 절차

5.73 g (39.8 mmol) of 2-methylenesuccinic acid 4-monomethyl ester were introduced into 12 ml of methanol under protective gas in a 50 ml glass autoclave, and 0.12 ml of a solution of 6.6 mg of (RophosARhCOD)CF3SO3 (=precatalyst) in 3 ml of methanol was added (0.00036 mmol of precatalyst). Hydrogenation was then carried out at 60° C. under 5 bar of hydrogen. Conversion of the precursor was complete after 16 h. The enantiomeric excess of the product was 98%.