Water → HCID 68781122, 화합물

HRID 2262891

반응식

HRID 2262891 반응식
Cl[C:2]1[S:6][N:5]=[C:4]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[N:3]=1.FC(F)(F)C(O)=O.[O:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[C:22]([NH:29][C:30]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[O:31])=[N:21]1.C(N(CC)CC)C.O>CN(C)C=O>[O:20]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[C:22]([NH:29][C:30]([N:32]2[CH2:37][CH2:36][N:35]([C:2]3[S:6][N:5]=[C:4]([N:7]4[CH2:12][CH2:11][O:10][CH2:9][CH2:8]4)[N:3]=3)[CH2:34][CH2:33]2)=[O:31])=[N:21]1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 568323194-(5-Chloro-1,2,4-thiadiazol-3-yl)morpholineHCID 68778018N-1,2-Benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate

생성물 1

HCID 68781122HCID 68781122, 화합물수율 38.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-(5-chloro-1,2,4-thiadiazol-3-yl)morpholine (114 mg, 0.555 mmol) and N-1,2-benzisoxazol-3-ylpiperazine-1-carboxamide trifluoroacetate (200 mg, 0.555 mmol) in N,N-dimethylformamide (2 ml) was added triethylamine (0.389 ml, 2.78 mmol) at room temperature, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured to water, and the precipitated solid was separated by filtration, which was recrystallized from a mixed solvent of methanol, ethyl acetate and tetrahydrofuran to give 89.4 mg (38.7%) of the desired product.

후처리

  1. customthe precipitated solid was separated by filtration, which
  2. customwas recrystallized from a mixed solvent of methanol, ethyl acetate and tetrahydrofuran

출처 및 근거

ORD 기록
ord-2b6f4a2eaeb6415d9d4f2d6b70dd4ed2
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07851473B2

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