참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 2-Amino-3-methylpyridine | HCID 15347 | — |
| 반응물 | Sodium Thiosulfate | HCID 24477 | — |
| 반응물 | Metaperiodic acid | HCID 65185 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Iodo-3-methylpyridin-2-amine | HCID 959586 | 174.9% |
반응 단계
To a solution of 3-methyl-2-pyridineamine (10 g) in a mixed solution of AcOH (60 mL), water (12 mL), and sulfuric acid (4.2 mL) was added periodic acid dehydrate (4.22 g) and iodine (9.39 g), and the mixture was heated at 80° C. for 2 hours. The reaction mixture was poured into 5% Na2S2O3 aq solution and extracted with ether. The organic layer was washed with 1N NaOH aq solution and brine, and dried over Na2SO4. The solvent was removed in vacuo and obtained residual solid was recrystallized with EtOH to give 5-iodo-3-methyl-2-pyridinamine (9.00 g) as pale yellow powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07557127B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-53f55ca96c1d4c3cab9aef891b414de3 |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
