1-(3-Methoxypropyl)piperazine → rac-[(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanone

참여 물질

역할	이름	HCID	투입량
반응물	1-(3-Methoxypropyl)piperazine	HCID 1822536	—
반응물	rac-(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 72455766	—
생성물	rac-[(4S,5R)-2-(4-tert-Butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazol-1-yl]-[4-(3-methoxy-propyl)-piperazin-1-yl]-methanone	HCID 58894305	—

반응 단계

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-2-(4-tert-butyl-2-isopropoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 1-(3-methoxy-propyl)-piperazine (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C39H51N4O3Cl2 [(M+H)+] 693.3333, observed 693.3334.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07851626B2
출처 데이터셋	uspto-grants-2010_12
ORD ID	ord-b0600981d7d94c8a9a60c9204803ba37
출처 메모	uspto-grants-2010_12