Sodium Methoxide → Methyl 3-methoxypyrazine-2-carboxylate

HRID 2264153노트

반응식

HRID 2264153 반응식
Br[C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][C:2]1[C:3]([C:8]([O:10][CH3:11])=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 13318551Methyl 3-bromopyrazine-2-carboxylate

생성물 1

HCID 21418987Methyl 3-methoxypyrazine-2-carboxylate

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 2 g of methyl 3-bromopyrazine-2-carboxylate (prepared as described by J. H. Jones, W. H. Holtz, E. J. C. Cragoe, J. Med. Chem., 1969, 12, 285-287) in 50 mL of methanol was added 4 mL of 30% NaOMe in methanol. After stirring 30 min the reaction was quenched with 6 mL of acetic acid and concentrated under reduced pressure. The residue was partitioned between 50 mL ethyl acetate and 50 mL saturated NaHCO3, the extract dried over MgSO4. Concentration under reduced pressure gave a white crystalline solid: MS (m+1)=169.1; 1H NMR (400 MHz, CDCl3) 8.3 (m, 2H), 4.1 (s, 3H), 4.0 (s, 3H).

후처리

  1. customwas quenched with 6 mL of acetic acid
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was partitioned between 50 mL ethyl acetate and 50 mL saturated NaHCO3
  4. dry with materialthe extract dried over MgSO4
  5. concentrationConcentration under reduced pressure
  6. customgave a white crystalline solid

출처 및 근거

ORD 기록
ord-f3a82a8a5dec4be69935fba377aaef3b
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855201B2

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