Dimethylformamide → HCID 16118433, 화합물

HRID 2264208노트

반응식

HRID 2264208 반응식
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[C:11]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[CH:10][C:9]([NH2:18])=[C:8]([NH2:19])[N:7]=1.C(N(CC)CC)C.CN(C)[CH:29]=[O:30]>>[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[N:7]=[C:8]2[NH:19][C:29](=[O:30])[NH:18][C:9]2=[CH:10][C:11]=1[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 59595986HCID 59595986, 화합물2회

생성물 1

HCID 16118433HCID 16118433, 화합물수율 45%

실험 절차

A solution of 2-(1,3-oxazol-2-yl)-3,4′-bipyridine-5,6-diamine (Intermediate 10, 0.077 g, 0.3 mmol), N,N′-carbonyldiimidazole (0.146 g, 0.9 mmol) and triethylamine (91 mg, 0.9 mmol) in N,N-dimethylformamide (1 mL) was heated to 100° C. in a sealed tube. After 4 hours, the mixture was cooled and concentrated in vacuo. Water was added to the residue and the solid that separated was washed with water and dried to give the title compound (0.038 g, 45%) as a white solid.

후처리

  1. temperaturethe mixture was cooled
  2. concentrationconcentrated in vacuo
  3. additionWater was added to the residue
  4. customthe solid that separated
  5. washwas washed with water
  6. customdried

출처 및 근거

ORD 기록
ord-4f670883641b495d8c2462d059301efb
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855202B2

반응 노트

불러오는 중…