Sulfuric Acid → 4-(2,4,5-Trifluorophenyl)cyclohexanone

HRID 2264284

반응식

HRID 2264284 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:19][CH2:18][C:13]2(OCC[O:14]2)[CH2:12][CH2:11]1.O1CCOCC1.S(=O)(=O)(O)O>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH:10]1[CH2:11][CH2:12][C:13](=[O:14])[CH2:18][CH2:19]1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 312751,4-DioxaneHCID 574243618-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane

생성물 1

HCID 574243624-(2,4,5-Trifluorophenyl)cyclohexanone

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

8-(2,4,5-Trifluorophenyl)-1,4-dioxaspiro[4.5]decane was added to a solution of 1,4-dioxane (600 mL), water (160 mL) and concentrated sulfuric acid (160 mL) and the resultant mixture was stirred for one h. The solution was then mixed with water (1 L) and extracted with dichloromethane (1 L). The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated to yield the title compound as a white solid.

후처리

  1. extractionextracted with dichloromethane (1 L)
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-a64f5721fff240538f659f7539af6f3f
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855206B2

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