Methyl Anthranilate → HCID 178515042, 화합물

HRID 2264382노트

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HRID 2264382 반응식
Cl[C:2]1[N:11]=[C:10]([O:12]CC)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:15](OC)(=[O:23])[C:16]1[C:17](=[CH:19][CH:20]=[CH:21][CH:22]=1)[NH2:18]>C(OCC)(=O)C>[OH:12][C:10]1[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]2[C:15](=[O:23])[C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=[C:2]2[N:11]=1

참가 물질

4

반응물 2

HCID 8635Methyl AnthranilateHCID 205064452-Chloro-4-ethoxyquinazoline

생성물 1

HCID 178515042HCID 178515042, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To the 2-chloro-4-ethoxy-quinazoline (500 mg, 2.40 mmol) in a boiling tube was added methyl anthranilate (372 μL, 2.88 mmol). The mixture was heated with a hot air gun (approx. 400 deg C.) for 15 minutes before cooling to room temperature. The resulting crude product was suspended in ethyl acetate (10 mL) and heated to boiling. The mixture was then cooled and the pure off-white product isolated by filtration (257 mg).

후처리

  1. temperatureThe mixture was heated with a hot air gun (approx. 400 deg C.) for 15 minutes
  2. temperatureheated to boiling
  3. temperatureThe mixture was then cooled
  4. customthe pure off-white product isolated by filtration (257 mg)

출처 및 근거

ORD 기록
ord-2c411c15cc0f45d2bf4910cbcc1c2221
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855214B2

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