Water → HCID 10200870, 화합물

HRID 2264518노트

반응식

HRID 2264518 반응식
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1.[CH2:29]([NH2:31])[CH3:30].O>C1COCC1>[CH2:29]([NH:31][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:3]=1)[CH3:30]

참가 물질

5

반응물 3

HCID 962WaterHCID 6341EthylamineHCID 17976006HCID 17976006, 화합물

생성물 1

HCID 10200870HCID 10200870, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

30 mg (0.08 mmol) of 2-chloro-4-(1,3-benzodioxol-5-yl)-6-benzyloxy-3,5-pyridinedicarbonitrile (example 4, step 1) and 10.4 mg (0.23 mmol) of ethylamine are shaken together in 0.12 ml of THF for about 16 h. Water is added to the reaction solution and the product that crystallizes out is filtered off with suction and dried under reduced pressure.

후처리

  1. customthe product that crystallizes out
  2. filtrationis filtered off with suction
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-cd5bf17a7b824c9a8f74ee4f29d801d6
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855219B2

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