Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 5-((6-Chloropyrimidin-4-yl)oxy)-1H-indole | HCID 57455156 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(6-Azido-pyrimidin-4-yloxy)-1H-indole | HCID 86234704 | — |
반응 단계
490 mg (2.0 mMol) 5-(6-chloro-pyrimidin-4-yloxy)-indole (WO 03/099771; Stage 163.1) and 260 mg (4.0 mMol) NaN3 in 3 ml DMF are stirred for 3 h at 90° C. Then the reaction mixture is poured into water and extracted three times with EtOAc. The organic layers are washed twice with water and brine, dried (Na2SO4) and concentrated, yielding the title compound: MS: [M+1]+=253.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07855215B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-15e27e7259fb44428da90c0ce67e12f8 |
| 출처 메모 | uspto-grants-2010_12 |