Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate → tert-Butyl 3-hydroxyphenethylcarbamate

HRID 2264660노트

반응식

HRID 2264660 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16]CC2C=CC=CC=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([OH:16])[CH:11]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 59596820Tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate

생성물 1

HCID 11031911tert-Butyl 3-hydroxyphenethylcarbamate수율 101.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

1 g of Pd/C 10% was added to a solution of 13 g (0.039 mol) of [2-(3-benzyloxy-phenyl)ethyl]-carbamic acid tert-butyl ester in 100 ml of ethanol. The mixture was hydrogenated at 40 psi overnight. The catalyst was filtered off and washed with ethanol. The solvent was removed under vacuum and 9.4 g of the title compound were obtained as a colourless oil in quantitative yield.

후처리

  1. customwas hydrogenated at 40 psi overnight
  2. filtrationThe catalyst was filtered off
  3. washwashed with ethanol
  4. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-cb56cc3514db4963bb776467a6312afc
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855227B2

반응 노트

불러오는 중…