Acetyl chloride → HCID 59596677, 화합물

HRID 2264823노트

반응식

HRID 2264823 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][C@H:11]([NH:16]C(OC(C)(C)C)=O)[C:12]([O:14][CH3:15])=[O:13])=[CH:4][CH:3]=1.C(Cl)(C)=O>CCOC(C)=O.CO>[NH2:16][C@@H:11]([CH2:10][C:9]#[C:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)[C:12]([O:14][CH3:15])=[O:13]

참가 물질

5

반응물 2

HCID 6367Acetyl chlorideHCID 59596703methyl (2S)-5-(4-bromophenyl)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-pentynoate

생성물 1

HCID 59596677HCID 59596677, 화합물수율 96%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of methyl (2S)-5-(4-bromophenyl)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-pentynoate (D74, 1.199 g, 3.136 mmol) in dry EtOAc (18 ml) and dry methanol (2 ml) was added AcCl (1.14 ml, 1.25 g, 15.98 mmol). After solvent removal the residue was purified using a SCX cartridge affording the title compound (849 mg, 95%). UPLC: Rt 0.51 min, MS: (ES/+) m/z: 282, 284 [MH+], C12H12BrNO2 requires 282.

후처리

  1. customAfter solvent removal the residue
  2. customwas purified

출처 및 근거

ORD 기록
ord-4926c98b4d204c85b9df5c775cf8541d
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855218B2

반응 노트

불러오는 중…