HCID 59596691, 화합물 → HCID 59596702, 화합물

HRID 2264827노트

반응식

HRID 2264827 반응식
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[CH:14]=[CH:13][C:12]([C@@H:15]3[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:18]([C:27]([O:29][CH3:30])=[O:28])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[C:1]1([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([C@@H:15]3[N:19]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[C@H:18]([C:27]([O:29][CH3:30])=[O:28])[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 59596691HCID 59596691, 화합물

생성물 1

HCID 59596702HCID 59596702, 화합물수율 92%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-{4-[(E)-2-phenylethenyl]phenyl}-1,2-pyrrolidinedicarboxylate (D79, 50 mg, 0.12 mmol) in methanol was added palladium (10 mg, 10 wt. % dry basis on activated carbon) and the mixture was stirred under hydrogen atmosphere (1 atm) for 4 h. A further addition of catalyst (20 mg) was required before the reaction was complete (as shown by HPLC). The catalyst was filtered off, the solvent removed under reduced pressure affording the title compound as a colourless oil (45 mg, 92%). Rt (HPLC): 7.04 min; MS: (ES/+) m/z: 432 [M+Na] C25H31NO4 requires 409.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-4fb85bf45e5c414fa35ef9af2c9fe9c4
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855218B2

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