Toluene → 80854-57-5

HRID 2265114노트

반응식

HRID 2265114 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1)=O.[C:13](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:15][CH2:16][CH3:17])=[O:14].[C:38]1(C)C=CC=CC=1>>[N+:10]([C:7]1[CH:8]=[CH:9][C:4](/[C:2](/[CH3:38])=[CH:1]/[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:5][CH:6]=1)([O-:12])=[O:11]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 7487p-NitroacetophenoneHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester

생성물 1

HCID 614540480854-57-5수율 29%

실험 절차

A toluene (90 ml) solution of 4-nitroacetophenone (2.0 g) and (carbethoxymethylidene)triphenylphosphorane (6.33 g) was stirred while refluxing under heating for 10 hours. After the solution was allowed to cool, the solvent was distilled off. The obtained residue was purified by column chromatography (6.25% ethyl acetate/n-hexane) to obtain Compound 19a (829 mg, 29%) as a white solid.

후처리

  1. temperaturewhile refluxing
  2. temperatureunder heating for 10 hours
  3. temperatureto cool
  4. distillationthe solvent was distilled off
  5. customThe obtained residue was purified by column chromatography (6.25% ethyl acetate/n-hexane)

출처 및 근거

ORD 기록
ord-d698436e2133487c8add22e095a73a7e
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855300B2

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