Ethyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]cinnamate → Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]phenyl]propanoate

HRID 2265117노트

반응식

HRID 2265117 반응식
[CH3:1][Si:2]([CH3:30])([CH3:29])[C:3]1[CH:4]=[C:5]([CH:22]=[C:23]([Si:25]([CH3:28])([CH3:27])[CH3:26])[CH:24]=1)[C:6]([NH:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:11][CH:10]=1)=[O:7].[H][H]>CO.C(OCC)(=O)C>[CH3:28][Si:25]([CH3:26])([CH3:27])[C:23]1[CH:22]=[C:5]([CH:4]=[C:3]([Si:2]([CH3:1])([CH3:30])[CH3:29])[CH:24]=1)[C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:20][CH:21]=1)=[O:7]

참가 물질

5

반응물 2

HCID 68487569Ethyl 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]cinnamateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 68485079Ethyl 3-[4-[[3,5-bis(trimethylsilyl)benzoyl]amino]phenyl]propanoate수율 99.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

Compound 17a (150 mg) was dissolved in methanol (35 ml) and ethyl acetate (35 ml). The obtained mixture was stirred for 30 minutes in a hydrogen atmosphere. After the reaction was over, the obtained reaction mixture was filtered through Cerite, and then washed with methanol. The solvent was distilled off from the filtrate, and the obtained residue was dried. Thus, Compound 20a (150 mg, quant.) was obtained as a white solid.

후처리

  1. customthe obtained reaction mixture
  2. filtrationwas filtered through Cerite
  3. washwashed with methanol
  4. distillationThe solvent was distilled off from the filtrate
  5. customthe obtained residue was dried

출처 및 근거

ORD 기록
ord-e5f4e8f7fcce40cbad5658a312266c25
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855300B2

반응 노트

불러오는 중…