3-Fluoro-5-(trifluoromethyl)benzeneboronic acid → 2-(3'-Fluoro-5-hydroxy-5'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:31])[CH:4]([C:9]1[CH:14]=[C:13]([O:15]S(C(F)(F)F)(=O)=O)[CH:12]=[C:11](OCC2C=CC=CC=2)[CH:10]=1)[CH2:5][C:6]([CH3:8])=[CH2:7].[F:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1>>[CH3:1][O:2][C:3](=[O:31])[CH:4]([C:9]1[CH:10]=[C:11]([C:35]2[CH:36]=[C:37]([C:39]([F:41])([F:40])[F:42])[CH:38]=[C:33]([F:32])[CH:34]=2)[CH:12]=[C:13]([OH:15])[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]참가 물질
3
실험 절차
The title compound was prepared in 73% yield from 2-(3-benzyloxy-5-trifluoromethanesulfonyloxy-phenyl)-4-methyl-pent-4-enoic acid methyl ester (prepared in Example 15, step (d)) under the conditions described in Example 15, step (e-f) using 3-fluoro-5-trifluoromethylphenylboronic acid in step (e).
출처 및 근거
- ORD 기록
- ord-4db8c7698c2a438583a62357213a7983
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07557244B2
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