3-Fluoro-5-(trifluoromethyl)benzeneboronic acid → 4-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3-fluoro-5-trifluoromethylphenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester

HRID 226523노트

반응식

HRID 226523 반응식
[CH3:1][O:2][C:3](=[O:27])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[CH:17]=2)[CH:12]=[C:13]([OH:15])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:28][C:29]1[CH:30]=[C:31](B(O)O)[CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=1>>[CH3:1][O:2][C:3](=[O:27])[CH:4]([C:9]1[CH:10]=[C:11]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([C:23]([F:26])([F:24])[F:25])[CH:17]=2)[CH:12]=[C:13]([O:15][C:31]2[CH:32]=[C:33]([C:35]([F:37])([F:36])[F:38])[CH:34]=[C:29]([F:28])[CH:30]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

참가 물질

3

반응물 2

HCID 27831923-Fluoro-5-(trifluoromethyl)benzeneboronic acidHCID 577549272-(4'-Chloro-5-hydroxy-3'-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester

생성물 1

HCID 577549914-Methyl-2-[4'-chloro-3'-trifluoromethyl-5-(3-fluoro-5-trifluoromethylphenoxy)-biphenyl-3-yl]-pentanoic acid methyl ester수율 50%

실험 절차

The title compound was prepared in 50% yield from 2-(5-hydroxy-4′-chloro-3′-trifluoromethyl-biphenyl-3-yl)-4-methyl-pentanoic acid methyl ester (prepared in Example A) and 3-fluoro-5-trifluoromethylphenylboronic acid under the conditions described in Example 15, step (g).

출처 및 근거

ORD 기록
ord-6b7fe30481664814b931d551f4724cb2
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557244B2

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