HCID 10203347, 화합물 → HCID 10154957, 화합물

HRID 2265332노트

반응식

HRID 2265332 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:23][CH2:24][CH2:25][O:26]C2CCCCO2)[C:11]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:6][CH:5]=1)([CH3:3])[CH3:2]>C(O)(=O)C.C1COCC1.O>[OH:26][CH2:25][CH2:24][CH2:23][N:10]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=1)[C:11]([CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1)=[O:12]

참가 물질

3

반응물 1

HCID 10203347HCID 10203347, 화합물

생성물 1

HCID 10154957HCID 10154957, 화합물수율 62%

시약·촉매·용매 1

HCID 21877175AcOH THF water용매

실험 절차

N-(4-Isopropylphenyl)-N-[3-(tetrahydropyran-2-yloxy)propyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.24 g) was dissolved in a mixed solvent (7 mL) of acetic acid: THF: water (4:2:1) and stirred at room temperature for 2 hr. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give N-(3-hydroxypropyl)-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.12 g).

후처리

  1. customThe reaction mixture was partitioned between water and ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-4ab274ab77d04a19819a647ff3b91e06
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07855297B2

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