4-Fluoro-2-(trifluoromethyl)aniline → HCID 57755022, 화합물

HRID 226547

반응식

HRID 226547 반응식
[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:38][C:39]1[CH:45]=[CH:44][C:42]([NH2:43])=[C:41]([C:46]([F:49])([F:48])[F:47])[CH:40]=1>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:31])([F:30])[F:32])[CH:26]=[C:25]([C:33]([F:34])([F:35])[F:36])[CH:24]=2)[CH:12]=[C:13]([NH:43][C:42]2[CH:44]=[CH:45][C:39]([F:38])=[CH:40][C:41]=2[C:46]([F:47])([F:48])[F:49])[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7]

참가 물질

3

반응물 2

HCID 678534-Fluoro-2-(trifluoromethyl)anilineHCID 57754914HCID 57754914, 화합물

생성물 1

HCID 57755022HCID 57755022, 화합물수율 46%

실험 절차

The title compound was prepared in 46% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Example 43, step (a)) and 4-fluoro-2-trifluoromethyl-aniline under the conditions described in Example 37, step (b).

출처 및 근거

ORD 기록
ord-28cfd4fe74b94b21a1db404a913060ba
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557244B2

연결된 노트

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