Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate
반응식
[OH:1][CH2:2][CH:3]1[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[OH:1][CH2:2][CH:3]1[CH2:6][NH:5][CH2:4]1참가 물질
3
실험 절차
To tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) was added trifluoroacetic acid (0.413 ml) while cooling in an ice bath, followed by stirring at the same temperature for 30 min. Then, the reaction mixture was stirred at room temperature for 1.5 hr. The reaction mixture was concentrated to provide a crude product of the titled compound as a yellow oil (209.8 mg).
후처리
- temperaturewhile cooling in an ice bath
- stirringThen, the reaction mixture was stirred at room temperature for 1.5 hr
- concentrationThe reaction mixture was concentrated
출처 및 근거
- ORD 기록
- ord-c1daa3081df14bdba06403a0247b4c26
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07855290B2
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