HCID 60135720, 화합물 → HCID 60135712, 화합물
반응식
[CH3:1][O:2][C:3](=[O:25])[CH:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14](=[O:24])[CH2:15][O:16]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:5]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:25])[CH:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14](=[O:24])[CH2:15][OH:16])=[CH:9][CH:8]=1)[CH3:5]참가 물질
4
실험 절차
2-[4-(2-Benzyloxy-acetoxy)-phenoxy]-propionic acid methyl ester 15 (13 grams, 37.79 mmol) is dissolved in methanol (100 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 10 grams) added and the mixture stirred under an atmosphere of hydrogen (4 Kg) for 48 hours. The catalyst is removed by filtration and distilled off the methanol. The crude 16 can be purified by column chromatography on silica gel using chloroform:Ethyl acetate.
후처리
- customThe catalyst is removed by filtration
- distillationdistilled off the methanol
- customThe crude 16 can be purified by column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-bacce61271b8477da01ad8e0da05c0b5
- 출처 데이터셋
- uspto-grants-2010_12
- 특허 번호
- US07858077B2
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