Chlorosulfonic acid → [2-(4-Fluorophenoxy)phenyl]sulfonyl chloride

HRID 2265876노트

반응식

HRID 2265876 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[F:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=1>ClCCl>[F:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[S:2]([Cl:1])(=[O:5])=[O:3])=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 676141-Fluoro-4-phenoxybenzene

생성물 1

HCID 5187142[2-(4-Fluorophenoxy)phenyl]sulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

16.1 g (0.138 mol) of chlorosulfonic acid are slowly added dropwise to a solution of 13.05 g of 4-fluorophenoxybenzene (0.069 mol) cooled to 0° C. After the addition is complete, the mixture is stirred at room temperature for a further 4 hours. For work up, 50 ml of dichloromethane are added, and the mixture is washed once with H2O. The aqueous phase is separated off and extracted twice more with 50 ml of dichloromethane each time. The combined organic phases are dried with MgSO4 and concentrated, resulting in the title compound as a colorless solid. Yield: 11.03 g; 60%.

후처리

  1. additionAfter the addition
  2. washthe mixture is washed once with H2O
  3. customThe aqueous phase is separated off
  4. extractionextracted twice more with 50 ml of dichloromethane each time
  5. dry with materialThe combined organic phases are dried with MgSO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-eb20f46957c549419a0abe64f464ee33
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858619B2

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