Water → HCID 66879234, 화합물

HRID 2265888노트

반응식

HRID 2265888 반응식
[F:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[O:25]C)(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br.O>ClCCl>[F:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[OH:25])(=[O:15])=[O:14])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 66879518HCID 66879518, 화합물

생성물 1

HCID 66879234HCID 66879234, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

620 mg (1.54 mmol) of 4-(4-fluorophenoxy)-N-[2-(2-methoxyphenyl)ethyl]benzene-sulfonamide are dissolved in 10 ml of dichloromethane and, at −40° C., 3.09 ml (3.09 mmol) of a 1 M solution of boron tribromide in dichloromethane are added. The solution is warmed to room temperature and stirred for a further four hours. It is subsequently added to water, the phases are separated, and the organic phase is washed twice more with H2O. The dichloromethane phase is dried with MgSO4 and concentrated, allowing the desired phenol to be isolated as a brown oil. Crude yield 89%.

후처리

  1. customthe phases are separated
  2. washthe organic phase is washed twice more with H2O
  3. dry with materialThe dichloromethane phase is dried with MgSO4
  4. concentrationconcentrated
  5. customto be isolated as a brown oil

출처 및 근거

ORD 기록
ord-bd7d4d5013464bef9b121b3e7369f436
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858619B2

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