3-Methoxypropyne → HCID 86625535, 화합물

반응식

Cl[C:2]1[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:3]=1[C:4]([N:6]([O:8][CH3:9])[CH3:7])=[O:5].[CH3:18][O:19][CH2:20][C:21]#[CH:22]>>[CH3:9][O:8][N:6]([CH3:7])[C:4](=[O:5])[C:3]1[CH:10]=[CH:11][C:12]([C:14]([F:17])([F:16])[F:15])=[N:13][C:2]=1[C:22]#[C:21][CH2:20][O:19][CH3:18]

참가 물질

반응물 2

HCID 693933-Methoxypropyne

HCID 59598164HCID 59598164, 화합물

생성물 1

HCID 86625535HCID 86625535, 화합물수율 22%

실험 절차

2-Chloro-N-methoxy-N-methyl-6-trifluoromethyl-nicotinamide (1000 mg, 3.72 mmol) was reacted with 3-methoxy-propyne (0.345 ml, 4.09 mmol) to give N-methoxy-2-(3-methoxy-prop-1-ynyl)-N-methyl-6-trifluoromethyl-nicotinamide (247 mg, 22%).

출처 및 근거

ORD 기록: ord-8e7313c0ea594e1083177f8ede04df43
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858621B2

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