Potassium Carbonate → 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

HRID 2266142노트

반응식

HRID 2266142 반응식
[CH:1]([C:4]1[C:9](S(C2C=CC(C)=CC=2)(=O)=O)=[CH:8][C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[C:6]([O:25][CH3:26])[CH:5]=1)([CH3:3])[CH3:2].C([O-])([O-])=[O:28].[K+].[K+]>CO>[CH:1]([C:4]1[CH:5]=[C:6]([O:25][CH3:26])[C:7]([C:20]2[N:21]=[CH:22][S:23][CH:24]=2)=[CH:8][C:9]=1[OH:28])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 595986244-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole

생성물 1

HCID 595986332-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-[4-Isopropyl-2-methoxy-5-(toluene4-sulfonyl)-phenyl]-thiazole (1.0 g, 2.27 mmol) and K2CO3 (1.6 g, 11.34 mmol) in anhydrous MeOH (10 ml) was refluxed for 8 hrs. Solvent was removed in vacuo and the residue was partitioned between methylene chloride and water. The combined organic extract was dried over Na2SO4, filtered, and concentrated to give 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol.

후처리

  1. temperaturewas refluxed for 8 hrs
  2. customSolvent was removed in vacuo
  3. customthe residue was partitioned between methylene chloride and water
  4. extractionThe combined organic extract
  5. dry with materialwas dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e62df7319f2e41c8a2404a0b6e44cb55
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858632B2

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