3-Ethoxyaniline → N2,N4-bis(3-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine

HRID 226629

반응식

HRID 226629 반응식
Cl[C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[CH2:10]([O:12][C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][CH:19]=1)[NH2:16])[CH3:11]>>[CH2:10]([O:12][C:13]1[CH:14]=[C:15]([NH:16][C:2]2[N:7]=[C:6]([NH:16][C:15]3[CH:17]=[CH:18][CH:19]=[C:13]([O:12][CH2:10][CH3:11])[CH:14]=3)[C:5]([F:9])=[CH:4][N:3]=2)[CH:17]=[CH:18][CH:19]=1)[CH3:11]

참가 물질

3

반응물 2

HCID 121203-EthoxyanilineHCID 2507052,4-Dichloro-5-fluoropyrimidine

생성물 1

HCID 22060949N2,N4-bis(3-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine

실험 절차

In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 3-ethoxyaniline were reacted to yield N2,N4-bis(3-ethoxyphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CD3OD): δ 7.96 (1H, d, J=4.8 Hz), 7.22 (m, 6H), 7.07 (t, 1H, J=1.8 Hz), 6.95 (dt, 1H, J=1.2 and 7.2 Hz), 6.77 (m, 2H), 3.88 (q, 4H, J=6.3 Hz), 1.33 (two t, 6H, J=6.3 Hz); 19F NMR (CDCl3): −46175; LCMS: ret. time: 26.86 min.; purity: 97%; MS (m/e): 369 (MH+).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-6adc0c4354784deda4be4fab7a33c7ef
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557210B2

연결된 노트

불러오는 중…