Chlorosulfonic acid → p-(2-Acetamidoethyl)benzenesulphonyl chloride

HRID 2266394노트

반응식

HRID 2266394 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH2:6]([NH:14][C:15](=[O:17])[CH3:16])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:15]([NH:14][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:10][CH:9]=1)(=[O:17])[CH3:16]

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 70143N-(2-phenylethyl)acetamide

생성물 1

HCID 3015782p-(2-Acetamidoethyl)benzenesulphonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

30.6 ml chlorosulfonic acid were added in one portion to 25.0 g N-phenethyl-acetamide. The reaction mixture was stirred at room temperature for one hour, then 100 ml dichloromethane were added and the reaction mixture was poured on ice water. The organic layer was separated washed twice with 50 ml brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 22.0 g 4-(2-Acetylamino-ethyl)-benzenesulfonyl chloride as a white solid.

후처리

  1. additionthe reaction mixture was poured on ice water
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-6cbc2ff5fa174d6185f6771accdfec30
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858647B2

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