Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethylamine → 5-chloro-2-methoxy-N-(2-phenylethyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethylamine | HCID 1001 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-Chloro-o-anisic acid | HCID 76970 | — |
| 반응물 | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-chloro-2-methoxy-N-(2-phenylethyl)benzamide | HCID 118575 | 90.6% |
반응 단계
3.0 g phenethylamine, 5.0 g 5-chloro-2-methoxy-benzoic acid, and 2.72 ml triethylamine were dissolved in 100 ml dimethylformamide. 8.80 g O-((Ethoxycarbonyl)cyanomethyleneamino)-N,N,N′,N′-tetramethyluronium tetrafluoroborate were added portionwise. The reaction mixture is stirred at room temperature for three hours. 300 ml ethyl acetate were added and the mixture was washed three times with portions of 50 ml saturated NaHCO3 solution and brine. The organic phase was dried over MgSO4 and then the solvent was removed in vacuo to obtain 6.5 g 5-Chloro-2-methoxy-N-phenethyl-benzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07858647B2 |
| 출처 데이터셋 | uspto-grants-2010_12 |
| ORD ID | ord-1e9175463bb945c39c9c4b4ecdec82de |
| 출처 메모 | uspto-grants-2010_12 |