Chlorosulfonic acid → 4-(2-((5-Chloro-2-methoxyphenyl)formamido)ethyl)benzene-1-sulfonyl chloride

HRID 2266402노트

반응식

HRID 2266402 반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([O:24][CH3:25])=[C:11]([CH:23]=1)[C:12]([NH:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13]>ClCCl>[Cl:6][C:7]1[CH:8]=[CH:9][C:10]([O:24][CH3:25])=[C:11]([CH:23]=1)[C:12]([NH:14][CH2:15][CH2:16][C:17]1[CH:18]=[CH:19][C:20]([S:2]([Cl:1])(=[O:5])=[O:3])=[CH:21][CH:22]=1)=[O:13]

참가 물질

4

반응물 2

HCID 24638Chlorosulfonic acidHCID 1185755-chloro-2-methoxy-N-(2-phenylethyl)benzamide

생성물 1

HCID 44545764-(2-((5-Chloro-2-methoxyphenyl)formamido)ethyl)benzene-1-sulfonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4.5 ml chlorosulfonic acid were added in one portion to 6.5 g 5-Chloro-2-methoxy-N-phenethyl-benzamide. The reaction mixture was stirred at room temperature for one hour, then 100 ml dichloromethane were added and the reaction mixture was poured on ice water. The organic layer was separated washed twice with 50 ml brine and then dried over MgSO4. The solvent was removed in vacuo to obtain 5.53 g 4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-benzenesulfonyl chloride.

후처리

  1. additionthe reaction mixture was poured on ice water
  2. customThe organic layer was separated
  3. washwashed twice with 50 ml brine
  4. dry with materialdried over MgSO4
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-0c300a18388c493fb0bf603caca3c355
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858647B2

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