p-Toluenesulfonic acid → 3-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

HRID 2266430노트

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HRID 2266430 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][CH:16]([C:20](=O)[CH3:21])[C:17](=O)[CH3:18])=[CH:13][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][C:16]2[C:20]([CH3:21])=[N:1][C:2]3[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([OH:9])[C:3]=3[C:17]=2[CH3:18])=[CH:13][CH:12]=1

참가 물질

4

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 14888033-[(4-Chlorophenyl)methyl]pentane-2,4-dioneHCID 30186673-Amino-5-methylphenol

생성물 1

HCID 1363463303-(4-Chlorobenzyl)-2,4,7-trimethylquinolin-5-ol

반응 조건

온도
160 °C

실험 절차

A mixture of 3-amino-5-methylphenol (1.0 g), 3-(4-chlorobenzyl)pentane-2,4-dione (1.7 g) and toluene-4-sulfonic acid (0.30 g) was heated at 160° C. under nitrogen for 3 hours. The mixture was cooled to room temperature and the residue triturated with methanol to give title compound, 1.5 g.

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. customthe residue triturated with methanol

출처 및 근거

ORD 기록
ord-f1acf58de28a45b6a0f12da71a887aaa
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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