Chlorodifluoromethane → HCID 68780083, 화합물

HRID 2266442노트

반응식

HRID 2266442 반응식
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8](=[O:26])[C:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)=[C:10]([CH3:17])[NH:11]2.C(=O)([O-])[O-].[K+].[K+].Cl[CH:35]([F:37])[F:36]>CN(C)C=O>[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]2[C:7]=1[C:8]([O:26][CH:35]([F:37])[F:36])=[C:9]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[C:10]([CH3:17])=[N:11]2

참가 물질

5

반응물 3

HCID 6372Chlorodifluoromethane2회HCID 11430Potassium CarbonateHCID 68782520HCID 68782520, 화합물

생성물 1

HCID 68780083HCID 68780083, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of [8-chloro-3-(4-chlorobenzyl)-2-methyl-4-oxo-1,4-dihydroquinolin-5-yloxy]acetic acid methyl ester (0.080 g), N,N-dimethylformamide (2.0 mL) and potassium carbonate (0.080 g) at −80° C. was added chlorodifluoromethane (0.4 mL). The flask was sealed and the resulting mixture warmed to room temperature and then stirred at this temperature for 17 hours. The excess chlorodifluoromethane was allowed to evaporate and the residue diluted with water and extracted with ethyl acetate. The combined extracts were washed with saturated aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed under reduced pressure to afford title compound as a light brown solid, 0.10 g.

후처리

  1. customThe flask was sealed
  2. customto evaporate
  3. additionthe residue diluted with water
  4. extractionextracted with ethyl acetate
  5. washThe combined extracts were washed with saturated aqueous sodium chloride solution
  6. dry with materialdried over magnesium sulfate
  7. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-fcf5de67f8e746ca99a2dfd1139c541a
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858640B2

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