3-Amino-4-fluorophenol → 2-(4-chlorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:28])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)[C:17](=[O:19])[CH3:18])(C)(C)C>>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][CH:16]([C:17](=[O:19])[CH3:18])[C:15]([NH:1][C:2]2[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=2[F:8])=[O:28])=[CH:26][CH:25]=1

참가 물질

반응물 2

HCID 135191803-Amino-4-fluorophenol

HCID 866314362-(4-chlorobenzyl)-3-oxothiobutyric Acid S-tert-butyl Ester

생성물 1

HCID 866314372-(4-chlorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

실험 절차

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(4-chlorobenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

출처 및 근거

ORD 기록: ord-91ffc770260c4697ac848c88968630b1
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858640B2

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