3-Amino-4-fluorophenol → 2-(2-chloro-4-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

반응식

[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:29])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[Cl:28])[C:17](=[O:19])[CH3:18])(C)(C)C>>[Cl:28][C:22]1[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:21]=1[CH2:20][CH:16]([C:17](=[O:19])[CH3:18])[C:15]([NH:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8])=[O:29]

참가 물질

반응물 2

HCID 135191803-Amino-4-fluorophenol

HCID 866314542-(2-chloro-4-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

생성물 1

HCID 866314552-(2-chloro-4-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

실험 절차

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(2-chloro-4-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

출처 및 근거

ORD 기록: ord-82fd6ba868094685b2e4c4b97ec7b464
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858640B2

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