(2-Methyl-furan-3-yl)-acetic acid ethyl ester → 2-(2-Methylfuran-3-yl)ethan-1-ol

HRID 2266813노트

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HRID 2266813 반응식
C([O:3][C:4](=O)[CH2:5][C:6]1[CH:10]=[CH:9][O:8][C:7]=1[CH3:11])C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:11][C:7]1[O:8][CH:9]=[CH:10][C:6]=1[CH2:5][CH2:4][OH:3]

참가 물질

4

반응물 2

HCID 14755481(2-Methyl-furan-3-yl)-acetic acid ethyl esterHCID 21226445Aluminium lithium hydride

생성물 1

HCID 184446362-(2-Methylfuran-3-yl)ethan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

A solution of (2-methyl-furan-3-yl)-acetic acid ethyl ester (11.8 g, 70.2 mmoles) in tetrahydrofuran (50 ml) was added to a stirred suspension of lithium aluminium hydride (2.66 g, 70.2 mmoles) under a nitrogen atmosphere and with cooling to 0° C. When the addition was complete the mixture was stirred at room temperature for 3 hours, then quenched by the addition of excess acetone. After acidifying with 10% aqueous hydrochloric acid the mixture was extracted three times with diethyl ether. The combined extracts were dried and evaporated to afford crude 2-(2-methyl-furan-3-yl)-ethanol as a yellow oil. (ii) Compound (70) was prepared in the form of a pale yellow oil from crude 2-(2-methyl-furan-3-yl)-ethanol (from (i)) by adapting the procedure of Example 1(a).

후처리

  1. additionWhen the addition
  2. customquenched by the addition of excess acetone
  3. extractionwas extracted three times with diethyl ether
  4. customThe combined extracts were dried
  5. customevaporated

출처 및 근거

ORD 기록
ord-f0d072bfbbd648fd8d53c1bd94449397
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858644B2

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