6′Chloro-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid isobutyl ester (54 mg, 0.18 mmol), 47.9 mg (0.22 mmol) of 2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenol, 3.2 mg (2.7 pmol) of Pd(PPh3)4, 49.2 mg (0.35 mmol) of K2CO3 were charged to a microwave reactor vial. The reaction mixture was heated by microwave irradiation at 120° C. for 15 minutes. The reaction was filtered and purified by reverse phase HPLC (10%-99% CH3CN/H2O), (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)) to give 33. LCMS: m/z 357.2 (M+H)+ at 3.53 minutes (10%-99% CH3CN/H2O), (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
