6-Chloro-3-pyridinecarbonitrile → 6-(3-(Hydroxymethyl)phenylthio)nicotinonitrile

반응식

[SH:1][C:2]1[CH:3]=[C:4]([CH2:8][OH:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][N:12]=1>>[OH:9][CH2:8][C:4]1[CH:3]=[C:2]([S:1][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][N:12]=2)[CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 51520946-Chloro-3-pyridinecarbonitrile

HCID 12813879(3-Sulfanylphenyl)methanol

생성물 1

HCID 685330886-(3-(Hydroxymethyl)phenylthio)nicotinonitrile수율 76%

실험 절차

Using the method of Preparation 155 using (3-mercaptophenyl)methanol (10.0 g, 71.3 mmol) and 6-chloronicotinonitrile (19.8 g, 142.7 mmol) affords the title compound (13.1 g, 76%): 243 (M+H, 100%).

출처 및 근거

ORD 기록: ord-efa98e6e2c3d429c953ae83cb236e891
출처 데이터셋: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07858646B2

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