2',4'-Dihydroxy-3'-propylacetophenone → HCID 68536988, 화합물

HRID 2267057

반응식

HRID 2267057 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=2)[C:15]#[N:16])[CH:6]=[CH:7][CH:8]=1.[OH:18][C:19]1[C:24]([CH2:25][CH2:26][CH3:27])=[C:23](O)[CH:22]=[CH:21][C:20]=1[C:29](=[O:31])[CH3:30]>>[C:29]([C:20]1[CH:21]=[CH:22][C:23]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([S:9][C:10]3[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=3)[C:15]#[N:16])[CH:6]=[CH:7][CH:8]=2)=[C:24]([CH2:25][CH2:26][CH3:27])[C:19]=1[OH:18])(=[O:31])[CH3:30]

참가 물질

3

반응물 2

HCID 27751982',4'-Dihydroxy-3'-propylacetophenoneHCID 685380695-(3-(Hydroxymethyl)phenylthio)nicotinonitrile

생성물 1

HCID 68536988HCID 68536988, 화합물수율 71.2%

실험 절차

Using the method of Preparation 160 using 5-(3-(hydroxymethyl)phenylthio) nicotinonitrile (3.90 g, 16.1 mmol) and 1-(2,4-dihydroxy-3-propylphenyl)ethanone (3.13 g, 16.1 mmol) affords the title compound (4.80 g, 71%): 1H NMR (CDCl3) δ 0.92 (t, J=7.2 Hz, 3H), 1.50-1.59 (m, 2H), 2.57 (s, 3H), 2.68 (t, J=7.6 Hz, 2H), 5.18 (s, 2H), 6.43 (d, J=9.0 Hz, 1H), 7.44-7.49 (m, 3H), 7.53 (s, 1H), 7.59 (d, J=9.0 Hz, 1H), 7.62 (dd, J=1.6, 2.3 Hz, 1H), 8.63 (dd, J=1.6, 2.3 Hz, 2H), 12.75 (s, 1H).

출처 및 근거

ORD 기록
ord-f1612a278e1b4518bb56c07b50a5fb83
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858646B2

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