1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 5-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio)nicotinonitrile

HRID 2267059노트

반응식

HRID 2267059 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=2)[C:15]#[N:16])=[CH:5][CH:4]=1.[OH:18][C:19]1[C:24]([CH3:25])=[C:23](O)[CH:22]=[CH:21][C:20]=1[C:27](=[O:29])[CH3:28]>>[C:27]([C:20]1[CH:21]=[CH:22][C:23]([O:1][CH2:2][C:3]2[CH:4]=[CH:5][C:6]([S:9][C:10]3[CH:11]=[N:12][CH:13]=[C:14]([CH:17]=3)[C:15]#[N:16])=[CH:7][CH:8]=2)=[C:24]([CH3:25])[C:19]=1[OH:18])(=[O:29])[CH3:28]

참가 물질

3

반응물 2

HCID 5921391-(2,4-Dihydroxy-3-methylphenyl)ethan-1-oneHCID 685358685-(4-(Hydroxymethyl)phenylthio)nicotinonitrile

생성물 1

HCID 685352345-(4-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio)nicotinonitrile수율 41%

실험 절차

Using the method of Preparation 160 using 5-(4-(hydroxymethyl)phenylthio) nicotinonitrile (1.20 g, 4.95 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (0.86 g, 5.20 mmol) affords the title compound (787 mg, 41%): 1H NMR (d6-DMSO) δ 2.06 (s, 3H), 2.58 (s, 3H), 5.30 (s, 2H), 6.72 (d, J=9.0 Hz, 1H), 7.51-7.55 (m, 4H), 7.81 (d, J=9.0 Hz, 1H), 8.23 (t, J=2.0 Hz, 1H), 8.72 (d, J=2.0 Hz, 2H), 8.91 (d, J=2.0 Hz, 1H), 12.85 (s, 1H).

출처 및 근거

ORD 기록
ord-4b4c35364d3549e0a0283accb06e4f81
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858646B2

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