1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 6-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile

HRID 2267070

반응식

HRID 2267070 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([S:9][C:10]2[N:11]=[CH:12][CH:13]=[C:14]([CH:17]=2)[C:15]#[N:16])[CH:6]=[CH:7][CH:8]=1.[CH2:18]([C:20]1[C:21]([OH:30])=[C:22]([C:27](=[O:29])[CH3:28])[CH:23]=[CH:24][C:25]=1O)[CH3:19]>>[C:27]([C:22]1[CH:23]=[CH:24][C:25]([O:1][CH2:2][C:3]2[CH:4]=[C:5]([S:9][C:10]3[N:11]=[CH:12][CH:13]=[C:14]([CH:17]=3)[C:15]#[N:16])[CH:6]=[CH:7][CH:8]=2)=[C:20]([CH2:18][CH3:19])[C:21]=1[OH:30])(=[O:29])[CH3:28]

참가 물질

3

반응물 2

HCID 212870211-(3-Ethyl-2,4-dihydroxyphenyl)ethanoneHCID 573554602-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile

생성물 1

HCID 685358456-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile수율 80%

실험 절차

Using the method of Preparation 166 using 6-(3-(hydroxymethyl)phenylthio) isonicotinonitrile (1.35 g, 5.56 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (1.00 g, 5.56 mmol) affords the title compound (1.80 g, 80%). MS (APCI-neg) m/z (rel intensity): 403 (M−H, 100%).

출처 및 근거

ORD 기록
ord-95babea68fc14ad389e2aff3300d1fa1
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858646B2

연결된 노트

불러오는 중…