Sodium Azide → 2-Azidopyridine

HRID 2267139노트

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HRID 2267139 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].[O-]S(C(F)(F)F)(=O)=O.F[N+:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CO>[N:1]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][N:14]=1)=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 2724576Pyridinium, 1-fluoro-, 1,1,1-trifluoromethanesulfonate (1:1)

생성물 1

HCID 109644722-Azidopyridine수율 82.3%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
-78 °C

실험 절차

Sodium azide (390 mg) was dissolved in 30 ml of methanol and cooled at −78° C., 6.0 ml of a methanolic solution of 740 mg of 1-fluoropyridinium triflate was dropped thereinto and the mixture was stirred for 4 hours. The solvent was evaporated in vacuo and the residue washed with 50 ml of diethyl ether to give 296 mg of the title compound in an ark oily crude product.

후처리

  1. customThe solvent was evaporated in vacuo
  2. washthe residue washed with 50 ml of diethyl ether

출처 및 근거

ORD 기록
ord-53dca0e895a142b4bbc7fae9b0477e87
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858800B2

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