N-Cyclopropylmethyl-N-(2-ethyl-7-iodopyrazolo[1,5-a]pyridin-3-yl)-N-tetrahydro-2H-4-pyranylmethylamine hydrochloride → N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine

HRID 2267198노트

반응식

HRID 2267198 반응식
Cl.[CH:2]1([CH2:5][N:6]([CH2:19][CH:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)[C:7]2[C:8]([CH2:17][CH3:18])=[N:9][N:10]3[C:15]([I:16])=[CH:14][CH:13]=[CH:12][C:11]=23)[CH2:4][CH2:3]1.O.C(=O)(O)[O-].[Na+]>C(OCC)(=O)C>[CH:2]1([CH2:5][N:6]([CH2:19][CH:20]2[CH2:21][CH2:22][O:23][CH2:24][CH2:25]2)[C:7]2[C:8]([CH2:17][CH3:18])=[N:9][N:10]3[C:15]([I:16])=[CH:14][CH:13]=[CH:12][C:11]=23)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 21084143N-Cyclopropylmethyl-N-(2-ethyl-7-iodopyrazolo[1,5-a]pyridin-3-yl)-N-tetrahydro-2H-4-pyranylmethylamine hydrochlorideHCID 86585896Sodium bicarbonate water

생성물 1

HCID 11339625N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine수율 88%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To N-cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine hydrochloride (16 g) was added saturated sodium bicarbonate water (200 mL) to give neutrality. Then, ethyl acetate (100 mL) was added to this, and an organic layer was separated. From the organic layer, the solvent was distilled off under reduced pressure. Into the resulting residue was dropped acetonitrile (30 mL) and water (120 mL), the mixture was stirred overnight, and the resulting precipitate was filtrated. The precipitate was dried under reduced pressure, and 13 g of a title compound was obtained as white crystal.

후처리

  1. customto give neutrality
  2. customwas separated
  3. distillationFrom the organic layer, the solvent was distilled off under reduced pressure
  4. additionInto the resulting residue was dropped acetonitrile (30 mL) and water (120 mL)
  5. filtrationthe resulting precipitate was filtrated
  6. customThe precipitate was dried under reduced pressure

출처 및 근거

ORD 기록
ord-b19a3fbd708d468ea5ce281b5fdcec74
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858809B2

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