Triethylamine → 1-(2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	N-(2-Aminoethyl)ethyleneurea	HCID 80480	—
반응물	4-(Benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine	HCID 57428827	—
용매	1-Methoxyethanol	HCID 3015637	—
생성물	1-(2-(4-(Benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)ethyl)imidazolidin-2-one	HCID 60204306	—

반응 조건

온도	100 °C

반응 단계

A mixture of 4-(benzo[b]thiophen-2-yl)-2-(methylsulfonyl)pyrimidine (75 mg, 0.26 mmol)), 1-(2-aminoethyl)imidazolidin-2-one (33 mg, 0.26 mmol) and triethylamine (32 mg, 0.31 mmol) in methoxyethanol (3 mL) was heated at 100° C. overnight. After cooling to rt the solvent was removed in vacuo and the product was purified by chromatography eluting with methanol/dichloromethane (1:20) to give the title compound as a slightly yellow solid (56 mg, 64%). MS (M+H)+ 340.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07858785B2
출처 데이터셋	uspto-grants-2010_12
ORD ID	ord-9a826142af904882a069e8aa429cf9b0
출처 메모	uspto-grants-2010_12