2-Chloro-1,1-dimethoxyethane → 2-(N-Methyl-N-phenylamino)thiazole

HRID 2267382

반응식

HRID 2267382 반응식
[CH3:1][N:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]([NH2:5])=[S:4].CO[CH:14](OC)[CH2:15]Cl>C1(C)C=CC=CC=1>[CH3:1][N:2]([C:3]1[S:4][CH:14]=[CH:15][N:5]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 609862-Chloro-1,1-dimethoxyethaneHCID 7236311-Methyl-1-phenylthiourea

생성물 1

HCID 234593752-(N-Methyl-N-phenylamino)thiazole

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 10 g (60 mmol) of N-methyl-N-phenylthiourea in 100 mL of toluene was treated with 7.2 mL (63 mmol) of chloroacetaldehyde dimethylacetal and heated at reflux for 12 h. The solvent was removed in vacuo and the residue purified by flash chromatography eluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane to deliver the title compound. MS (M+H)+ 191.

후처리

  1. temperatureheated
  2. temperatureat reflux for 12 h
  3. customThe solvent was removed in vacuo
  4. customthe residue purified by flash chromatography
  5. washeluting with a linear gradient of 30% EtOAc in hexane to 80% EtOAc in hexane

출처 및 근거

ORD 기록
ord-c367ec944d73486e8c63d7a0c8109701
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858785B2

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