Ethanol → 4-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

HRID 2267758노트

반응식

HRID 2267758 반응식
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([O:15][CH2:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)[CH:11]=[CH:10][CH:9]=2)=[O:5])C.[OH-].[K+].CCO>>[CH:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:13]=2[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]3)[CH2:18][CH2:19][CH2:20][CH2:21]1

참가 물질

4

반응물 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 668413514-Cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 668411204-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

실험 절차

The 4-cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester 87 obtained above is mixed with a 2M-solution of KOH in EtOH (33.8 ml, 67.6 mmol) and stirred for 24 hours. The solvent is then evaporated and the residue is partitioned between water and ether. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a white powder.

후처리

  1. customThe solvent is then evaporated
  2. customthe residue is partitioned between water and ether
  3. extractionextracted twice with EtOAc
  4. washThe combined organic layers are washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customto give a white powder

출처 및 근거

ORD 기록
ord-281620a0e99b4ce099dfec8cc795a844
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858781B2

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