Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2268생성일: 2026년 10월 23일
Potassium Carbonate → 4-tert-butyl-N-[5-(3-methoxyphenoxy)-6-{2-(2-pyrimidinylamino)ethoxy}-pyrimidin-4-yl]benzenesulfonamide hydrate
https://huagongshe.com/ko/reaction/2268
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Dimethylacetamide | HCID 31374 | — |
| 반응물 | 2-Chloropyrimidine | HCID 74404 | — |
| 반응물 | N-{6-(2-aminoethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl}-4-tert-butylbenzenesulfonamide hydrochloride | HCID 67654095 | — |
| 용매 | Ammonium Chloride | HCID 25517 | — |
| 생성물 | 4-tert-butyl-N-[5-(3-methoxyphenoxy)-6-{2-(2-pyrimidinylamino)ethoxy}-pyrimidin-4-yl]benzenesulfonamide hydrate | HCID 19689482 | 161.1% |
반응 단계
A mixture of Compound A (150 mg), 2-chloropyrimidine (61 mg), potassium carbonate (122 mg) and dimethylacetamide (1.5 ml) is heated with stirring at 100° C. for three days. The reaction solution is diluted with aqueous ammonium chloride solution, and extracted with ethyl acetate. The extract is washed and dried. The solvent is evaporated to remove the solvent, and the residue is purified by silica gel column chromatography (solvent; chloroform/methanol=100:1) and further recrystallized from ethyl acetate/n-hexane to give 4-tert-butyl-N-[5-(3-methoxyphenoxy)-6-{2-(2-pyrimidinylamino)ethoxy}-pyrimidin-4-yl]benzenesulfonamide hydrate (135 mg) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05728706 |
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| 출처 데이터셋 | uspto-grants-1998_03 |
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| ORD ID | ord-1febdfb0ad8749368c5d7d698e941579 |
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| 출처 메모 | uspto-grants-1998_03 |
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