Methanol → Methyl p-aminosalicylate

HRID 226801

반응식

HRID 226801 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:11])[CH:3]=1.[CH3:12]O>>[OH:11][C:4]1[CH:3]=[C:2]([CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH3:12])=[O:7])[NH2:1]

참가 물질

3

반응물 2

HCID 887MethanolHCID 46494-Aminosalicylic Acid

생성물 1

HCID 77787Methyl p-aminosalicylate

실험 절차

A solution of 4-amino-2-hydroxybenzoic acid (1 g, 6.5 mmol) in MeOH (15 mL) and concentrated sulfonic acid (1 mL) was refluxed overnight. The reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL). The organic layer was separated, dried, evaporated to give 3-hydroxy-4-methoxycarbonylaniline.

후처리

  1. customThe reaction mixture was quenched with NaHCO3 aqueous solution (60 mL) and EtOAc (60 mL)
  2. customThe organic layer was separated
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-2e59af37f17b4ef4879d0356c4247e47
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557210B2

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