Tetrahydrofuran → HCID 66647628, 화합물

HRID 2268138노트

반응식

HRID 2268138 반응식
CO[C:3]1[C:4](=O)[NH:5][CH:6]=[CH:7][CH:8]=1.Cl.Cl.[CH:12]1([NH:17][NH2:18])CCCC1.[O:19]1CCCC1>>[N:18]1[C:3]2[CH:8]=[CH:7][CH:6]=[N:5][C:4]=2[C:12](=[O:19])[N:17]=1

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 887313-Methoxy-2-pyridoneHCID 18349526Cyclopentylhydrazine dihydrochloride

생성물 1

HCID 66647628HCID 66647628, 화합물

반응 조건

온도
88 °C

실험 절차

treating said 3-methoxy-pyridinone compound of Formula (7.0.0) with cyclopentylhydrazine dihydrochioride; wherein a reaction mixture is established with tetrahydrofuran (THF) solvent and heating of said reaction mixture to 88° C., for 12 hours, while said reaction mixture is being swept by nitrogen in order to remove methanol, THF, and HCl; whereby there is produced a pyrazolopyridinone compound N-protected by p-methoxybenzyl, of Formula (8.0.0):

후처리

  1. additiontreating
  2. customreaction mixture
  3. customto remove methanol, THF, and HCl

출처 및 근거

ORD 기록
ord-1d7f7bb51af94a55aaa0def4df02b40a
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06326495B2

반응 노트

불러오는 중…